Aromatase Inhibition in Boys with Delayed Puberty: Effects on Growth, Maturation, Bone, Serum Lipids, and Insulin
نویسندگان
چکیده
6 LIST OF ORIGINAL PUBLICATIONS 8
منابع مشابه
Pharmacological management of children with short stature: the role of aromatase inhibitors.
OBJECTIVE To review the use of aromatase inhibitors, a novel treatment strategy for patients with short stature, which aims at delaying bone age advancement. Skeletal maturation is estrogen-dependent even in male children. SOURCES We performed a MEDLINE search of studies published in the last 10 years, including aromatase, short stature, and early puberty as keywords. The most informative art...
متن کاملBlockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition.
OBJECTIVE In males, the pubertal increase in sex hormone production has been associated with proatherogenic changes in lipid and carbohydrate metabolism. Aromatase inhibitors, a novel treatment modality for some growth disorders, may significantly influence these risk factors for cardiovascular disease by suppressing oestrogen biosynthesis and stimulating gonadal androgen production. In the cur...
متن کاملUse of aromatase inhibitors in precocious puberty.
During puberty, estrogen causes breast maturation and growth of the uterine lining in girls, and accelerates linear growth and bone maturation in both boys and girls. Decreasing the biosynthesis of estrogen can attenuate these processes. In 12 girls with the McCune-Albright syndrome (MAS), in which precocious puberty is due to production of estrogen from ovarian cysts, testolactone (40 mg/kg pe...
متن کاملEunice Kennedy Shriver National Institute of Child Health and Human Development ( NICHD ) Obstetric and Pediatric Pharmacology Branch ( OPPB ) Best Pharmaceuticals for Children Act ( BPCA ) Selected Citations – Aromatase Inhibitors
PURPOSE OF REVIEW: Delayed puberty in men is a commonly presenting problem to paediatricians and an understanding of the available evidence on cause, treatments and outcomes is important to guide practice. RECENT FINDINGS: Understanding of the regulation of the onset of puberty is gradually unfolding, although the genetic factors that dictate the timing of puberty in individuals and families re...
متن کاملWhether all patients with Central precocious puberty should be treated?
Extended Abstract Precocious puberty is the appearance of secondary sexual characteristics before 8 years old in girls and 9 years old in boys. Precocious puberty is divided into 3 groups of central, peripheral and normal variants. Central precocious puberty is accompanied by activation of hypothalamic-pituitary-gonadal axis which causes increase in secretion of GnRH, and in turn increase i...
متن کامل